Home Health 79% of the risk of schizophrenia can be explained by genetic factors

79% of the risk of schizophrenia can be explained by genetic factors

This is the revealing conclusion of the largest study of twins on this serious mental illness.


Approximately 500,000 Spaniards and 21 million people worldwide suffer from schizophrenia, a mental illness that, according to a report just published in the Canadian Medical Association Journal, triples the risk of mortality among those affected. On average, schizophrenics usually die eight years earlier than people without this ailment, as they would be more exposed to insane habits such as smoking and sedentary lifestyle, as well as the side effects of medication they take.

It is estimated that in our country the costs associated with schizophrenia amount to 8,000 million Euros, and it is the third cause of disability among the young population. It is therefore a serious public health problem in which it is a priority to find out its causes and determine the best ways to prevent and treat it.

The latest news comes from the University of Copenhagen in Denmark, whose researchers have announced the findings of the largest study on this psychiatric disorder conducted with twins. And their data confirm the importance of the inheritance factor: 79% of the risk of contracting it would be explained exclusively for genetic reasons. The paper, which has been echoed in the journal Biological Psychiatry, attempted to refine the results of previous statistical studies, based on whether individuals were suffering at that time schizophrenia or not, without assessing the risk of contracting it later.

Hunting the gene

Dr. John Krystal, Director of Biological Psychiatry , has put into context the figure estimated by the Danish specialists: ” this 79% is at the upper end of the percentages proposed so far , ranging from 50% to 80% which supports the intense scientific efforts to locate the genes responsible for schizophrenia. ”

Experts at the University of Copenhagen have taken advantage of the comprehensive database of the Danish Twin Register, in which all twins born in Denmark are registered since 1870, compared with the Danish Psychiatric Central Research Register. In the end, researchers have been able to examine the cases of more than 30,000 pairs of twin siblings.

In addition, the research has taken into account other disorders that are not strictly schizophrenia, but belong to the same spectrum of psychiatric disorders. And in this case, the heritability index is also very high: it amounts to 73%.

“Our study is the most complete and rigorous estimate of the genetic component of schizophrenia and its diagnostic diversity,” says Hilker Rikke, one of the authors of the report. Because, as this specialist also points out, the weight of the congenital factor is practically equal in all manifestations of the disease, which can produce from mild symptoms to completely incapacitate the affected.

One of the latest advances in this regard is the discovery of a rare genetic variant, called RTN4R that can play a decisive role in the development of schizophrenia, as Japanese researchers have suggested in the journal Translational Psychiatry. This DNA fragment is associated with the production of myelin, a substance that acts as the conductor of electrical signals between neurons, and whose abundance or absence is directly related to the correct functioning of the brain.

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