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Men with a curved penis have a higher risk of cancer

Peyronie syndrome or "twisted penis" is associated with a higher prevalence of urological, stomach and melanoma-like tumors, according to a study.

Men with a curved penis have a higher risk of cancer

Men who have a certain condition that curves the  penis have a significantly higher risk of suffering from certain types of cancer, according to a new study from the Baylor College of Medicine presented at the American Society of Reproductive Medicine, based on the results of one million and half of patients.

In particular, the risk of malignant tumor rises by 40% in cases of testicular and stomach cancer; and it is 29% higher in the melanoma type  in men who have this condition, commonly known as twisted penis, bent penis or curved penis.

What is the relationship? It is not clear. But, as the researchers suggest, the same gene that determines this curvature of the penis could also regulate the development of certain tumors.

We are talking, however, of a curvature with its own name. This is the so-called Peyronie syndrome, by which fibrous structures are formed inside the cavernous bodies of the penis, causing this characteristic curvature during erection. It affects approximately 7% of males

A condition that, although it may seem like a simple physical anomaly, can be symptomatic of a more serious problem.

The researchers started from a genetic analysis of a father and his son, both with Peyronie syndrome: they discovered that both shared genes that made them more predisposed to suffer from these three types of cancer: testicular, stomach and melanoma.

This same relationship was observed in a detailed study, which included a million and a half men.

The results are alarming enough for the team of researchers to recommend increasing the screening of these three types of cancer (testicular, stomach and melanoma) in men with curvature of the penis.

“Although the data have no influence on the sexual and reproductive life of these patients, they should be monitored for risk of more serious disorders, in contrast to the rest of the population,” according to Dr. Alexander Pastuszak, principal investigator. Nobody has made an association like this until now. ”

Although, for scientists, the relationship between the curvature of the penis and the higher incidence of cancer is clear, the causes of this syndrome are not well known, nor why it is a risk factor for cancer. However, the researchers are sure that it shares genetic pathways with, at least, these three types of tumors.

Precisely for this reason, the researchers encourage to increase the specific screening programs in men with this characteristic, given that doing so would provide extra data and would allow reaffirming or refuting the conclusions of the study.

Extending data extracted from the study, the condition of penile curvature or Peyronie syndrome also share a molecular pathway with Dupurytren’s disease, a deformity of the hand; and also with the disease of lead, a thickening of the tissue of the feet.

According to researchers at the University of Istanbul, it is believed that Peyronie affects 7.1% of men, but the actual prevalence of the disease may be higher because patients, surely, are reluctant to report this “embarrassing” condition to your doctor.

Although, given the results of the Baylor College of Medicine, it is important that men who possess this characteristic go without hesitation to periodic reviews with the urologist.


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